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Statins For Prostate Cancer
Prevention? (October 2004)
A
56% reduction in risk of prostate cancer resulting from statin usage was
reported in abstract form at 2004 ASCO Annual Meeting based on a pilot
study conducted at the Oregon Health & Science University. The case
controlled study compared 47 men with prostate cancer with 147 PSA normal
clinic controls. Higher dosages and longer usage, > 3 years, of any
type of statin were risk lowering. The mechanism of action is thought to
be different from that which lowers cholesterol and probably involves
unexpected interaction in an unsuspected signaling pathway. The evidence
for risk reduction in prostate cancer is in line with a major 2004 ASCO
report from researchers at the University of Michigan based on their
Molecular Epidemiology of Colorectal Cancer Study which found that any
type of statin medication used for a minimum of five years was associated
with a 51% reduction in the risk of colorectal cancer. The results from
these studies will certainly lead to follow-up.
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