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PSA doubling time predicts likelihood
of distant failure. (October 2002)
In an editorial ( JCO, August 1,2002 )
Dr. D'Amico discusses the issue of predicting prostate cancer specific
death (PCSD) when the PSA rises post treatment. A rapid rise ( PSA
Doubling Time: 6-12 months) significantly predicts distant failure. A
post-RT PSA DT <1 year was associated with PCSD of 52% v. 10% for DT >1
year (p=.007). D'Amico briefly refers to data from his institution showing
PSA DT < 1 year also is associated with an overall all-cause death rate of
53%. This fact will lead in a later commentary to a discussion of the
recently published Scandinavian study comparing rates of PCSD with
all-cause death.
Bottom Line: Post treatment PSA DT predicts for distant failure and death
and can therefore guide treatment decisions.
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