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Free PSA further refined to assist
clearer diagnostic implications. (October 2002)
Coming soon: further analysis of serum
PSA. In the June 2002 issue of Urology Mikolajczyk presents a review,
"Free Prostate-Speficic Antigen In Serum Is Becoming More Complex." As we
know, serum PSA is a serine protease that circulates in the serum bound by
alpha-1-antichymotrypsin, which renders PSA inactive. Unbound PSA also
circulates, and the new analysis finds that the "free PSA" has three
components. Precursor PSA (pPSA) is associated with cancer; BPSA is a
degraded PSA largely associated with BPH; and the third is a form that is
a variant of PSA but similar to active PSA.
Bottom Line: Further analysis of pPSA amd BPSA will advance the
understanding of prostate diseases.
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