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Clinical usefulness of serum prostate specific antigen for
the detection of prostate cancer is preserved in men receiving the dual
5alpha-reductase inhibitor dutasteride [0.5 mg/d]
(October 2006)
J.Urol. May 2006. It has been reasonable to assume that,
just as for finasteride, the PSA value should be doubled during
dutasteride treatment. Andriole et al. from a study of 2802 >50 year old
cancer free men with BPH and PSA values ranging from 1.5 - 10 ng/mL
concluded, "A doubling factor is effective for maintaining the sensitivity
and specificity for detection of prostate cancer in men on dutasteride".
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