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Defining Biochemical Recurrence of Prostate Cancer After
Radical Prostatectomy: A Proposal for a Standardized Definition
(October 2006)
JCO, August 2006. Scardino et al. argue that a PSA value of
"at least 0.4 ng/mL followed by another increase best explained metastatic
progression". The analysis controlled for clinical variables and was based
on follow-up of 3125 men post-RP. Ten candidate definitions of recurrence
were considered among which the 10-year progression-free probability
ranged from 63% to 79%.
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